Study about Paternal Age: an approach towards Considerable Confounding Risk Factor in Chromosomal Aneuploidies

Abstract

The chromosomal aneuploidies associated with advanced  maternal age has been widely discussed  and debated over decades. The paternal age effect associated with aneuploidies was underreported with limited evidence which left room for analysis and discussion. The researchers in a retrospective study, observed the paternal age of three chromosomal aneuploidies from the Indian population. The paternal age was included in the patient data with confirmed karyotype. The paternal age was divided  into two groups: <30 years  and  >30 years. With the help of Linear regression analysis the correlation of paternal age with children born with aneuploidies was analysed. The researchers made an interesting observation: paternal age was statistically significant as a confounding risk factor in chromosomal aneuploidy in both age categories for Down and Turner syndrome. These findings highlighted the importance of taking a strategic approach to the treatment of couples who are at risk of cytogenetic abnormalities.  The correlation of chromosomal aneuploidies and the effect of young paternal age is an interesting factor raised and opened for further investigation and discussion to the future investigators.