A Brief Study on Sirtuins: An Approach to Novel Pharmacological Target

Abstract

The primary goal of this research is to determine the precise role of Sirtuins in physiology and pathology. Is it possible to identify sirtuins as a novel pharmacological target that can be easily manipulated by inhibitors or activators?

Natural products, semi-synthetic, synthetic and repurposing drugs such as alpha lipoic acid, resveratrol, vitamin D3, GLP-1, DPP-4 inhibitors, gene therapy with apelin, Icariin, coumestrol, dietary fatty acids, melatonin, Honokiol, SRT1460 etc. SIRT is a promising target for a variety of diseases and catastrophic complications, including metabolic, cardiovascular, neurological, neuropsychiatry, neurodegenerative, diabetes, and diabetic complications such as neuropathy, nephropathy, and retinopathy. It's also a possible target for osteoporosis, bone disorders, age-related alterations, male and female infertility, obesity, and metabolic syndrome. SIRT inhibitors can be used as anticancer agents. However, very few drugs specific SIRT activators are under investigation.