Evaluation of Antioxidant Potential and Pro-Inflammatory Enzymes Inhibitory Activity of Fractions and Macerate from Pandiaka angustifolia (vahl) Hepper

Authors

  • A. M. E. Thiombiano Laboratory of Biochemistry and Applied Chemistry (LABIOCA), UFR/SVT, 09 BP 848 Ouagadougou 09, University of Ouagadougou, Burkina Faso.
  • Hilou Adama Laboratory of Biochemistry and Applied Chemistry (LABIOCA), UFR/SVT, 09 BP 848 Ouagadougou 09, University of Ouagadougou, Burkina Faso.
  • Bangou Mindiédiba Jean Department of Biochemistry and Microbiology/ Training and Research Unit in Life and Earth Science, Nazi BONI University, Bobo-Dioulasso, Burkina Faso.
  • Bagora Bayala Centre de Recherche Biomoléculaire Pietro Annogoni, Saint Camille-CERBA/ LABIOGENE- Ouagadougou, Université de Ouagadougou, 03 BP 7021 Ouagadougou 03, Burkina Faso.
  • Ouattara Nabèrè Laboratory of Biochemistry and Applied Chemistry (LABIOCA), UFR/SVT, 09 BP 848 Ouagadougou 09, University of Ouagadougou, Burkina Faso.
  • Guenné Samson Laboratory of Biochemistry and Applied Chemistry (LABIOCA), UFR/SVT, 09 BP 848 Ouagadougou 09, University of Ouagadougou, Burkina Faso.
  • Meda Nâg-Tiero Roland Laboratory of Biochemistry and Applied Chemistry (LABIOCA), UFR/SVT, 09 BP 848 Ouagadougou 09, University of Ouagadougou, Burkina Faso.
  • Compaoré Moussa Laboratory of Biochemistry and Applied Chemistry (LABIOCA), UFR/SVT, 09 BP 848 Ouagadougou 09, University of Ouagadougou, Burkina Faso.
  • Kiendrébeogo Martin Laboratory of Biochemistry and Applied Chemistry (LABIOCA), UFR/SVT, 09 BP 848 Ouagadougou 09, University of Ouagadougou, Burkina Faso.
  • Millogo F. Jeanne Laboratory of Biology and Plants Ecology, UFR/SVT, 09 BP 848 Ouagadougou 09, University of Ouagadougou, Burkina Faso.
  • Nacoulma O. Germaine Laboratory of Biochemistry and Applied Chemistry (LABIOCA), UFR/SVT, 09 BP 848 Ouagadougou 09, University of Ouagadougou, Burkina Faso.

DOI:

https://doi.org/10.9734/bpi/napr/v6/5770B

Keywords:

Pandiaka angustifolia, antioxidant activity, LOX, XO, phenolic content

Abstract

In traditional medicines of Burkina Faso, a variety of ailments are treated with Pandiaka angustifolia (Vahl) Hepper, a shrub from the Amaranthaceae family. Amaranthaceae is one of the families of plants that are frequently used to treat disease. This investigation was made to assess the lipoxygenase and xanthine oxidase inhibitory potentials of hydroacetonic macerate and fractions of Pandiaka angustifolia, as well as the amount of phenolics and flavonoids, antioxidant capacity, and other properties. The findings showed  the Dichloromethane Fraction (DCMF) possess the best inhibitory activity of lipoxygenase, a key enzyme involved in inflammatory process with 83.84±1.89% of inhibition, as regards Xanthine Oxidase (XO) inhibiting percentage, n-hexane fraction (n-HF) exhibited the highest percentage of inhibition with 76.22 ± 4.78% at a concentration of 100µg/ml. Evaluation of the phenolic and flavonoid content of the fractions and hydroacetonic macerate revealed that the dichloromethane fraction (DCMF) had the highest phenolic and flavonoid content, respectively. This study demonstrated that P. angustifolia's apolar fractions are a viable natural source for the treatment of disorders associated with inflammation and oxidative stress.

Published

2023-07-25

How to Cite

A. M. E. Thiombiano, Hilou Adama, Bangou Mindiédiba Jean, Bagora Bayala, Ouattara Nabèrè, Guenné Samson, … Nacoulma O. Germaine. (2023). Evaluation of Antioxidant Potential and Pro-Inflammatory Enzymes Inhibitory Activity of Fractions and Macerate from Pandiaka angustifolia (vahl) Hepper. Novel Aspects on Pharmaceutical Research Vol. 6, 1–11. https://doi.org/10.9734/bpi/napr/v6/5770B

Issue

Novel Aspects on Pharmaceutical Research Vol. 6

Section

Chapters