Potential Role of Punica Granatum (Pomegranate) in Management of COVID-19: A Review

Abstract

Viral infections suppress immune system of the host. SARS-CoV-2, Just like other viral infections weaken the host immunity. A strong immune system is the key to protection from virus and other pathogens. Severe cases admitted to the intensive care unit showed high level of pro-inflammatory cytokines which enhanced the disease severity. Antioxidant medications are suggested as a current course of treatment for patients who have the SARS-CoV-2 virus.It raises glutathione and oxygen levels, which strengthens the immune response. The results include a decrease in the amount of time required for mechanical ventilation, the prevention of multiple organ dysfunctions, a shorter hospital stay, and a lower mortality rate.  Immune modulation is the only way of regulation of the immune system. Punica Granatum has been used as a traditional medicine for centuries. The components of this plant are known for its rich immune-regulation, anti-inflammatory, and antioxidant benefits in specially in respiratory disorders. Many of the study results are based on in vitro and cell-based assays. It necessitates further confirmation of in vivo efficacy through human clinical trials.