Method Development and Validation for the Estimation of Bortezomib in Pure and Its Pharmaceutical Tablet Dosage form by UV Spectroscopy

Authors

  • R. Nageswara Rao Department of Pharmaceutical Analysis, Santhiram College of Pharmacy, Nandyal-518501, Andhra Pradesh, India.
  • V. Ravikumar Department of Pharmaceutical Biotechnology, School of Pharmacy, Guru Nanak Institutions Technical Campus , Hyderabad, Telangana, India.
  • L. Shiva Shankar Reddy Department of Pharmaceutical Analysis, Santhiram College of Pharmacy, Nandyal-518501, Andhra Pradesh, India.
  • D. Madhuri Department of Pharmaceutical Analysis, Creative Education Society’s College of Pharmacy, NH-7, Chinnetekur, Kurnool-518218, A. P. India.
  • N. Yellasubbaiah Department of Pharmaceutical Analysis, Santhiram College of Pharmacy, Nandyal-518501, Andhra Pradesh, India.
  • S. V. Suresh Kumar Department of Pharmaceutical Analysis, Santhiram College of Pharmacy, Nandyal-518501, Andhra Pradesh, India.
  • N. Madana Gopal Department of Pharmaceutical Analysis, Santhiram College of Pharmacy, Nandyal-518501, Andhra Pradesh, India.
  • S. Indradev Department of Pharmaceutical Analysis, Creative Education Society’s College of Pharmacy, NH-7, Chinnetekur, Kurnool-518218, A. P. India.
  • S. Vinay Department of Pharmaceutical Analysis, Creative Education Society’s College of Pharmacy, NH-7, Chinnetekur, Kurnool-518218, A. P. India.
  • S. Mahesh Department of Pharmaceutical Analysis, Creative Education Society’s College of Pharmacy, NH-7, Chinnetekur, Kurnool-518218, A. P. India.
  • P. Ajay Kumar Department of Pharmaceutical Analysis, Creative Education Society’s College of Pharmacy, NH-7, Chinnetekur, Kurnool-518218, A. P. India.

DOI:

https://doi.org/10.9734/bpi/napr/v1/6009A

Keywords:

Bortezomib, UV spectroscopy, velcade, validation, ICH guidelines

Abstract

Background: Bortezomib is an anti-cancer medication used to treat multiple myeloma and mantle cell lymphoma.

Methods: The UV Spectroscopy method for analysis of bortezomib was developed and validated as per ICH guidelines. The estimation of bortezomib in the pure and tablet dosage form was carried out at the maximum absorbance at 365 nm.

The Results: The method was found to be linear and obeys beers law in the concentration range 5-25µg/ml with a correlation coefficient 0.999, the developed method was validated as per ICH guidelines and was found to be accurate and precise.

Conclusion: A rapid novel precise and accurate UV Spectroscopy method was developed and validated and can be used for regular analysis for the estimation of bortezomib.

Published

2023-04-19

How to Cite

R. Nageswara Rao, V. Ravikumar, L. Shiva Shankar Reddy, D. Madhuri, N. Yellasubbaiah, S. V. Suresh Kumar, … P. Ajay Kumar. (2023). Method Development and Validation for the Estimation of Bortezomib in Pure and Its Pharmaceutical Tablet Dosage form by UV Spectroscopy. Novel Aspects on Pharmaceutical Research Vol. 1, 154–164. https://doi.org/10.9734/bpi/napr/v1/6009A

Issue

Novel Aspects on Pharmaceutical Research Vol. 1

Section

Chapters