Metaplastic Squamous Cell Carcinoma of Breast: A Rare Case Report

Abstract

Metaplastic carcinoma of breast is rare variant of breast carcinoma with varying histology and a generally poor prognosis depending on the histological subtype in addition to classical prognostic factors. It’s triple negative status further compounds the poor clinical behaviour of these carcinomas. A variable percentage of the glandular epithelial cells that make up the tumour have undergone transformation into an alternative cell type, either a nonglandular epithelial cell type or a mesenchymal cell type, making metaplastic breast carcinomas a morphologically heterogeneous group of invasive breast cancers. Metaplastic carcinomas are uncommon lesions, representing less than < 5% of all invasive breast cancer. This is a case of 51 year old female with left breast swelling since 3 months. She underwent Modified Radical Mastectomy. The gross appearance of metaplastic carcinoma is not distinctive and these tumors can either be well-circumscribed or show an indistinct irregular border. Better systemic therapy is therefore needed to improve patient outcomes. Therefore, pathological examination of these breast lump and other body lesion is must.