Study on Synthesis, Characterization and Biological Evaluation of Novel 2-aryl-5-(Arylsulfonyl)-1,3,4-oxadiazole Derivatives

Abstract

Oxadiazoles with plethora of biological applications are identified as important motifs for the advance of innovative drug design, thus grabbing the attention of medicinal chemists around the world. Especially, 1,3,4-oxadiazole and its derivatives are playing a vital role in medicinal chemistry with broad range of biological applications. This chapter summarizes the synthesis, characterization of ten novel 2-aryl-5-(arylsulfonyl)-1,3,4-oxadiazoles (6a-j) and evaluation of in vitro antibacterial and antioxidant activities. The in vitro antimicrobial screening against bacterial strains Pseudomonas aeruginosa, Enterobacter aerogenes, Escherichia coli (gram-positive), and Bacillus cerus, Staphylococcus aureus, Bacillus subtilis (gram-negative) revealed that the prepared 2-(3,4-dimethylphenyl)-5-tosyl-1,3,4-oxadiazole (6j), 2-(3-isopropylphenyl)-5-tosyl-1,3,4-oxadiazole (6c), and 2-(2-ethylphenyl)-5-tosyl-1,3,4-oxadiazole (6i) are most potent among all the investigated compounds. In addition, via the DPPH radical scavenging method some of the prepared compounds show moderate antioxidant activity.