Cadaverine on Polymer Support: A Study on Solid Phase Synthesis

Abstract

In chemistry, solid-phase synthesis is a method in which molecules are covalently bound on a solid support material and synthesised step-by-step in a single reaction vessel utilising selective protecting group chemistry. Benefits compared with normal synthesis in a liquid state include High efficiency and throughput and Increased simplicity and speed. The reaction can be driven to completion and high yields through the use of excess reagent. In this method, building blocks are protected at all reactive functional groups. Cadaverine is a polyamine that naturally occurs and is closely related to spermine and spermidine, two important polyamines that control the growth of living things. Cadaverine was created using polystyrene as a solid support and a photocleavable linker. Filtration and washing with appropriate solvents are the only purification steps utilized throughout the synthesis. Cadaverine was initially synthesized on a polystyrene support and then photolytically separated from the matrix. Utilizing variously cross-linked polystyrene resins with divinyl benzene serving as the cross-linking agent, the yield and purity of the sample were examined. One photocleavable linker's impact was investigated. Linker was created using a traditional organic synthetic process.