Combining Effect of Zn2+, Cu2+, Co2+ and Ni2+ Complexes Containing Chiral Amino Alcohols: Synthesis, Characterization and their Anticancer Activities

Abstract

Coordination complexes play a crucial role in modern research studies. Amino alcohols are a fascinating class of molecules with numerous chemical applications, including the synthesis of pharmaceuticals and valuable chiral chemicals, and biological applications, such as antibacterial and tuberculostatic medicines, HIV protease inhibitors, intermediates in organic synthesis, and organic catalysis. Because of their bifunctional nature, amino alcohols can react in several ways. These multifunctional molecules are extensively applied in medicinal chemistry, synthetic pharmaceuticals, synthetic amino acids, and chiral auxiliaries for enantioselective synthesis. Our research team synthesized seven novel complexes, [NiC₁₅H₄₃N₅O₁₁] (I), [Co₃C₃₆H₉₈N₆O₆] (II), [CuC₁₄H₃₂N₂O₆] (III), [Cu₂C₃₂H₄₃Cl₂N₂O₁₃] (IV), [Zn₂C₂₄H₃₂Cl₃N₃O₃] (V), [Co₃C₄₈H₆₆Cl₆N₆O₆] (VI), and [Zn (C₁₈H₄₅N₃O₃] (VII), separately from the direct reaction of ligands containing amino alcohols with metal salts, such as anhydrous methanol or ethanol. The crystal structures of complexes (I)-(VII) were determined by X-ray diffraction and further characterized by elemental analysis, IR, NMR, and UV–Vis. The anticancer activity of amino alcohol complexes (I)–(VII) exerted cytotoxic effects against the human tumour cell Line A549; among them, complex V showed the best activity with an IC₅₀ value of 17.8.