Metal Complexes in Biology and Medicine (Part- Mercury(II) / Nickel(II) /Lead(II) – Isoleucine)

Abstract

Metal ions are fundamental elements for the maintenance of the life spans of the human, animals and plants. Metal based drugs bioactivity can be increased by metal chelation, which in turn increase their absorbance and stability. The stability constants of Hg²⁺, Ni²⁺ and Pb²⁺ complexes with isoleucine were determined by paper ionophoretic technique.  Present method is based upon the migration of a spot of metal ions on a paper strip at different pHs of background electrolyte.  A graph of pH against mobility gives information about the binary complexes and permit to calculate their stability constants.  The first and second stability constants of [Hg(II) – isoleucine], [Ni(II) – isoleucine] and [Pb(II) – isoleucine] complexes were found to be (8.80 ± 0.02, 7.52 ± 0.03), (7.27 ± 0.01, 5.86 ± 0.03) and (7.17 ± 0.05, 3.32 ± 0.09) for Hg(II), Ni(II) and Pb(II) complexes, respectively at 0.01 M ionic strength and a temperature of 35° C. Metal complexes can offer their action such as antidiabetic, antimicrobial, anti-inflammatory anti-cancer and anti- thyroid compounds. Lead is one of the toxic metal whose chemical bonding results in effect on the nervous, hematopoietic, renal and vascular systems.