9H-Carbazole-3-carbaldehyde-4-phenylthiosemicarbazone, 10-Hexyl-10-H-phenothiazine-3-carbaldehyde-4-phenylthio semicarbazone and 2-Thiophenecarboxaldehyde-4-Methylthiosemicarbazone and their Metal Complexes: Synthesis and Anti-bacterial Activity Studies

Abstract

The present study reports the synthesis and characterization of copper(II) complexes of 9H-Carbazole-3-carbaldehyde-4-phenylthiosemicarbazone (Cu-CCPTSC), 10-Hexyl-10-H-pheno thiazine-3-carbaldehyde-4-phenylthiosemicarbazone (Cu-HPCPTSC), 2-Thiophenecarboxalde -hyde-4-methylthiosemicarbazone (Cu-TCMTSC) with FT-IR, XRD and thermogravimetric analysis. Antibacterial activities of both chelating agents and their copper complexes against two gram positive bacterial stains, Bacillus subtilis, Staphylococcus aureus and two gram negative bacterial stains, Pseudomonas aeruginosa, Escherichia coli.

Organic chelating agents plays an important role in both analytical and biological fields. Among organic reagents, thiosemicarbazones have a vital role due to the ability of formation of bonds with enzymes in biological systems. The donor atoms of nitrogen and sulphur of thiosemicarbazones forms a chelating bonds with the wide range of metal ions. There are numerous thiosemicarbazones with a wide range of uses in the chemical and pharmaceutical industries that we may find in the literature. But given that they are still useful in contemporary chemistry, there is still room to create novel thiosemicarbazone ligands and associated metal complexes. Finally, the antibacterial activities of both chelating agents and their metal complexes are tested with two gram positive bacterial stains, such as Bacillus subtilis, Staphylococcus aureus and two gram negative bacterial stains, Pseudomonas aeruginosa, Escherichia coli. The activity of CCPTSC and TCMTSC against E.coli almost doubled due to chelation with copper(II) ions. Cu-CCPTSC complexes shows higher activity against P. aeruginosa while other complexes are having with S. aureus.