Novel Approaches for Solubility Enhancement

Abstract

The phenomenon of solubility involves the dissolution of a solid in a liquid phase to produce a homogenous molecular dispersion. Oral delivery is the most common pharmaceutical administration route due to its ease for patients to take, high compliance rates, ability to develop various dosage form options and lower (on average) overall cost of drug formulation. However, the majority of the active pharmaceutical components are hydrophobic and poorly soluble in water. A drug’s therapeutic effectiveness depends upon bioavailability and ultimately upon the solubility of drug molecules especially in oral formulation. The drug's solubility becomes one of the most challenging in formulation development. Therefore, despite their potential pharmacokinetic action, many newer medicines' poor water solubility is a key barrier to their successful market introduction. Solubility problems are faced in the Class II drugs and Class IV drugs of the BCS system. So, to overcome the problem of solubility many conventional methods as well as novel methods have been developed. Novel methods have been developed to overcome the disadvantages of conventional and enhancing the solubility of poorly soluble drugs.