A Brief Study on Type 2 Diabetes Mellitus and Benfotiamine

Abstract

Benfotiamine (BFT) supplementation may provide benefits in the prevention of other diabetes-related vascular and neuronal comorbidities. The mechanism of BFT influence on diabetic angio, neuropathies pathogenesis is not well-known. This mini-review was aimed to analyze the latest evidence about the effects of benfotiamine (a lipid-soluble thiamine derivative with higher bioavailability than thiamine) on some metabolic and functional parameters in type 2 diabetes mellitus (T2DM) patients with diabetic angio-, neuropathies. Further investigations aimed to understand the mechanism of action and for confirmation of the beneficial effect of BFT on biochemical parameters, dynamics of independent cardiovascular tests, daily monitoring of electrocardiography, arterial wall stiffness parameters among patients with type 2 diabetes mellitus, diabetic angio-, neuropathies and its associated comorbidities may be needed to validate these clinical findings.