Prognostic Factors and Postoperative Survival in Clear Cell Renal Carcinomas. A Histopathological Diagnosis

Abstract

Introduction: Clear cell Renal Cell Carcinoma (ccRCC) is the most common type of Renal Cell Carcinoma that occurs in adults and it has the worst prognosis among the common epithelial tumors of these organs. This neoplasm is characterized by a high blood supply. With this in mind, we have used the CD34, an endothelial antigen that has been used to highlight the microvessel density (MVD), as a direct marker of neoangiogenesis degree.

Objective: To establish the correlation between CD34 and other prognostic factors like Fuhrman nuclear degree and tumoral size.

Material and Methods: Tumour samples from 17 patients with histopathology diagnosis of ccRCC were examined by immunohistochemical staining for CD34. The CD34 expression was analyzed by Anova and Student Newman Multiple Comparison Test and Tuckey as a post-test, and finally, we used a Spearman Correlation to compare with the other prognostic factors analyzed and Kaplan Meier survival analysis for the disease-free survival of the patients.

Results and Conclusion: There is a negative correlation between the MVD and the Fuhrman nuclear grade, whereas R = -0,46; and p < 0,05 and there is a positive correlation between the MVD and the maximum tumour diameter, whereas R = 0,47 and p < 0,05. In conclusion, we found that a high MVD is related to a low Fuhrman nuclear grade and a high tumour size. The possible significance of this study can be that in fact, we need more than one parameter to predict the biological behavior of the ccCCR.