Study on Mammary Analogue Secretary Carcinoma: A Rare Salivary Gland Tumor

Abstract

Introduction: Mammary analogue secretary carcinoma are salivary gland tumours that are histologically similar to breast secretory carcinomas. It mainly affects adults between the ages of 45 and 65. Clinically, it is typically a slow-growing, low-grade malignancy with a good prognosis.

Objective: To study the clinicopathological features of mammary analogue secretary carcinoma of salivary glands.

Case Report:  We are reporting a case of a 47-year-old female who has been complaining of swelling behind her left ear for the past 7 years.It grew slowly, painlessly, and persistently. On examination, 4 x 3 cm swelling was present just below left ear lobule. It was nontender, firm, irregular in shape with smooth surface with slight mobility and overlying skin pinchable. A benign tumour with cystic alteration was found using fine needle aspiration cytology (FNAC).A lobulated hypodense lesion measuring 24 x 35 x 32 mm with internal septations and wall enhancement was found on a contrast enhanced computed tomography scan at the expected site of the superficial and deep lobes of the left parotid gland. Histopathology revealed secretory analogue mammary carcinoma after the patient underwent left complete conservative parotidectomy. She was then given post-operative radiation. Patient is being followed up on a regular basis and is currently disease-free.

Conclusion:  Mammary analogue secretory carcinoma is often a low-grade malignancy with a favourable prognosis. The presence of S-100 protein and mammaglobin is confirmed by immunohistochemistry.