Study on Influence of Abnormal GCT with Normal or Impaired OGTT on Neonatal Outcome

Abstract

The screening test for diabetes mellitus during pregnancy is done for all the pregnant women by Glucose Challenge Test (GCT) and if raised oral Glucose Tolerance Test ( OGTT) is done. In this study, single elevated 100gm OGTT value associated with effects on the neonate out come like, APGAR Score, large for gestational age & hyperbilirubinemia were studied in 500 pregnant women. GCT was considered high if the glucose level was >140 mg/dl and are considered as positive and OGTT were done with 100 gm glucose. The result of our study suggest that having a positive GCT is an independent risk factor for adverse neonatal outcome like large for gestational age 2.2% in normal GTT group in compared to 10.8% in impaired GTTgroup, and hyperbilirubinemia were significantly high in those patients. Gestational diabetes mellitus is diagnosed by a 2-step method, with a 3-hour, 100-g oral glucose tolerance test that is reserved for women with an abnormal 1-hour, 50-g glucose challenge test. Although the increased maternal-fetal morbidity with gestational diabetes mellitus is well established, controversy remains about the risk that is associated with an isolated abnormal value during a 3-hour, 100-g oral glucose tolerance test [1,2]. The result of Chaturvedi [3] suggest that having a positive GCT is an independent risk factor for adverse perinatal outcome like preeclamsia, post partum hemorrhage, and incidence of ceaserian sections were significantly high in these patients.