A Comprehensive Review on Tumor Cavity Stereotactic Radiosurgery for Resected Brain Metastases

Authors

  • Yasemin Bolukbasi Department of Radiation Oncology, School of Medicine, Koc University, Istanbul, Turkey and Department of Radiation Oncology, The University of Texas, MD Anderson Cancer Center, Houston, TX, USA.
  • Ugur Selek Department of Radiation Oncology, School of Medicine, Koc University, Istanbul, Turkey and Department of Radiation Oncology, The University of Texas, MD Anderson Cancer Center, Houston, TX, USA.
  • Duygu Sezen Department of Radiation Oncology, School of Medicine, Koc University, Istanbul, Turkey and Department of Radiation Oncology, The University of Texas, MD Anderson Cancer Center, Houston, TX, USA.
  • Nulifer Kilic Durankus Department of Radiation Oncology, School of Medicine, Koc University, Istanbul, Turkey.
  • Eyub Yasar Akdemir Department of Radiation Oncology, School of Medicine, Koc University, Istanbul, Turkey.
  • Sukran Senyurek Department of Radiation Oncology, School of Medicine, Koc University, Istanbul, Turkey.
  • Ahmet Kucuk Mersin City Education and Research Hospital, Radiation Oncology Clinics, Mersin, Turkey.
  • Berrin Pehlivan Department of Radiation Oncology, Bahcesehir University, Istanbul, Turkey.
  • Erkan Topkan Department of Radiation Oncology, Medical Faculty, Baskent University, Adana, Turkey.

DOI:

https://doi.org/10.9734/bpi/hmmr/v2/2350E

Keywords:

Brain metastases, stereotactic radiosurgery, neurosurgery, postoperative cavity radiosurgery, toxicity, efficacy, prognosis

Abstract

Stereotactic radiosurgery (SRS) has been utilized broadly for brain metastases not only for intact ones but as well as of late for the postoperative cavity of metastases after surgery, due to the advantages of SRS to preserve neurocognitive functions, maintain local control and prescribe the treatment in a short time frame. Randomized trials have proven the safety and efficacy of cavity SRS compared to observation. As WBRT offers no survival advantage in comparison to SRS and frequent monitorization with brain MRIs for early salvage upon failure, there has been a revolution in clinical approach for patients with limited intact brain metastases to treat with SRS only and omit WBRT. The recent implementation of the PO-SRS applications to the treatment algorithm of resected BMs has reputably enhanced the local control at the surgical resection bed in comparison to observation or WBRT Likewise, the postoperative cavity SRS for brain metastases has gained a growing reputation. In this review, we summarize the proof for evidence-based optimization in the postoperative setting of the surgically removed brain metastases.

Published

2021-02-13

How to Cite

Yasemin Bolukbasi, Ugur Selek, Duygu Sezen, Nulifer Kilic Durankus, Eyub Yasar Akdemir, Sukran Senyurek, … Erkan Topkan. (2021). A Comprehensive Review on Tumor Cavity Stereotactic Radiosurgery for Resected Brain Metastases. Highlights on Medicine and Medical Research Vol. 2, 146–164. https://doi.org/10.9734/bpi/hmmr/v2/2350E

Issue

Highlights on Medicine and Medical Research Vol. 2

Section

Chapters