COVID-19, Immune System and Hi-D FACS: A Review

Abstract

Hi-D immunophenotyping of peripheral blood from COVID-19 patients revealed a significant shift in the ratio of immune cells, especially between mature and immature neutrophils associating with severity. Hi-D FACS has also confirmed absolute numbers of lymphocyte subsets were differentially decreased in COVID-19 patients according to clinical severity. Using Hi-D FACS for understanding immune responses in the context of clinical severity is foundation to overcome the lack of effective anti-viral immune response in severely affected COVID-19 patients and can offer prognostic value as biomarker for disease outcome and control.