Current Topics in Medicine and Medical Research Vol. 13,
29 April 2021,
Background: The accurate mechanisms of the neuropsychiatric involvement of celiac disease (CD) are not absolutely known. Different mechanisms have been suggested. Gluten toxicity, and, as a result, hyper-homocysteinemia (hyperHcy), may be the most suspicious triggering risk factors in the pathogenesis of neuropsychiatric manifestations of CD.
Methods: PubMed/Medline, Web of Science, and Google Scholar were searched to find all of the published data on the relationship between hyperHcy, CD, and neuropsychiatric manifestations.
Conclusions: Until know, there has been no conclusive evidence about relationship between hyperHcy and the neuropsychiatric manifestations of CD. Based on these data, more future studies are needed to evaluate and discuss in detail hyperHcy in the pathophysiological pathways of CD with clinical or subtle neuropsychiatric involvement.