Evaluation of Schiff Bases Derived from 1,8-diaminonaphtalène: An Approach towards Its Synthesis, Characterization and Biological Activities

Abstract

This chapter evaluates the synthesis, Characterization and Biological Activity of Schiff Bases derived from 1,8-diaminonaphtalène.  Schiff bases are the most widely used organic compounds. They have been shown to exhibit a broad range of biological activities, including antifungal, antibacterial, antimalarial, antiproliferative, anti-inflammatory, antiviral, and antipyretic properties. Salicylaldehyde, Ortho-Vanilline, and benzene-1,8-diaminonaphtalene were procured from Aldrich and used without further purification. The compound have been synthesized and characterized by routine MS, IR and NMR spectrometry methods. The compounds are all active on bacterial strains with the exception of Salmonella typhimirium, with a MIC value of 7.5 mg / mL. They show a percentage of anti-radical activity of 75.476 ± 5.070 for the compound DAN-S and of 68.142 ± 6.539 for the compound DAN-OV. The less substituted DAN-S compound is more active as shown in the histogram. For these molecules, this is the first time, our knowledge, that such important antioxidant properties have been observed.