Phytochemical Assessment of Bioactive Constituents Derived from Punica granatum, Eriobotrya japonica and Musa acuminata Extracts against Hyperglycemic-induced Oxidative Trauma in Rat Model: A Histopathological Exploration

Authors

  • Rahat Mustafa Department of Chemistry, The University of Lahore, Lahore, Pakistan.
  • Shahana Rahat Department of Anesthesia, Evercare Hospital Lahore, Lahore, Pakistan.
  • Mazhar Abbas Department of Basic Sciences (Section Biochemistry), University of Veterinary and Animal Sciences, Lahore (Jhang-Campus), Jhang, Pakistan.
  • Munawar Iqbal Department of Chemistry, Division of Science and Technology, University of Education, Lahore, Pakistan.
  • Arif Nazir Department of Chemistry, The University of Lahore, Lahore, Pakistan.

DOI:

https://doi.org/10.9734/bpi/ctcb/v9/17967D

Keywords:

Phytochemicals, antidiabetic, oxidative stress, histopathology, plant leaf extract, `

Abstract

The antidiabetic and antioxidant properties of the leaf extracts of Punica granatum, Eriobotrya japonica and Musa acuminata were investigated using normal and streptozocin (STZ) induced diabetic rats. The diabetes in rats was induced by injecting STZ (40 mg/kg) intraperitoneally. The crude methanolic leaf extracts of P. granatum, E. japonica, and M. acuminata were administered orally to the diabetic rats at a dose of 50 mg/kg for 28 days, along with the standard drug glimepiride (2 mg/kg). The effect of the leaf extracts on glucose tolerance was also tested in non-diabetic rats. Blood glucose levels were measured at 0, 30, 60, and 120 minutes after administration. The results were analyzed using two-way Analysis of Variance and expressed as standard deviation. The results showed that the leaf extracts have noteworthy antidiabetic and antioxidant properties. These medicinal plants have the prospective to be an economical source of indigenous medicine for the treatment of diabetes.

Published

2023-02-28

How to Cite

Rahat Mustafa, Shahana Rahat, Mazhar Abbas, Munawar Iqbal, & Arif Nazir. (2023). Phytochemical Assessment of Bioactive Constituents Derived from Punica granatum, Eriobotrya japonica and Musa acuminata Extracts against Hyperglycemic-induced Oxidative Trauma in Rat Model: A Histopathological Exploration. Current Topics on Chemistry and Biochemistry Vol. 9, 63–76. https://doi.org/10.9734/bpi/ctcb/v9/17967D

Issue

Current Topics on Chemistry and Biochemistry Vol. 9

Section

Chapters