Synthesis and Characterization of Some Biologically Active Fluorinated Heterocycles Like Benzothiazepines & Pyrazolines

Abstract

Fluorinated heterocycles like benzothiazepines & Pyrazolines shows marked biological activities. 4-Bromo-2-fluorobenzaldehyde 1 when treated with substituted hydroxy acetophenones 2 yields chalcones 3. These chalcones were refluxed with 2-aminothiophenol gave “2-[2-(4-bromo-2-fluorophenyl)-2,3-dihydro-1,5-benzothiazepin-4-yl]phenol” 4 and when treated with hydrazine hydrate gave the compound “2-[5-(4-bromo-2-fluorophenyl)-4, 5-dihydro-1H-pyrazol-3-yl]phenol” 5. On the basis of spectral data, the structures of compounds have been constructed.