L-Proline Catalyzed Transamidation of Thioamides with Amines

Authors

  • Sadu Nageswara Rao Academy of Scientific and Innovative Research, CSIR–Central Salt and Marine Chemicals Research Institute, G.B. Marg, Bhavnagar-364 002. Gujarat, India.
  • Darapaneni Chandra Mohan Academy of Scientific and Innovative Research, CSIR–Central Salt and Marine Chemicals Research Institute, G.B. Marg, Bhavnagar-364 002. Gujarat, India.
  • Subbarayappa Adimurthy Academy of Scientific and Innovative Research, CSIR–Central Salt and Marine Chemicals Research Institute, G.B. Marg, Bhavnagar-364 002. Gujarat, India.

DOI:

https://doi.org/10.9734/bpi/ctcb/v8/4940E

Keywords:

Thioamides, amines, l-proline, transthioamidation

Abstract

L-Proline catalyzed transthioamidation of primary thioamides with amines under solvent-free conditions has been characterised. The catalyst L-proline is commercially available and required low catalyst loading. L-Proline promotes the reaction through hydrogen bond formation with amines. A wide variety of amines can be transthioamidated with yields of up to 97%. The reactions proceed through ionic pathway under neat conditions.

Published

2023-01-23

How to Cite

Sadu Nageswara Rao, Darapaneni Chandra Mohan, & Subbarayappa Adimurthy. (2023). L-Proline Catalyzed Transamidation of Thioamides with Amines. Current Topics on Chemistry and Biochemistry Vol. 8, 123–133. https://doi.org/10.9734/bpi/ctcb/v8/4940E

Issue

Current Topics on Chemistry and Biochemistry Vol. 8

Section

Chapters