Development of an Analytical Method and Validation of Exemestane Tablet by UV Spectrophotometry

Abstract

This chapter discusses the development and validation of a UV spectrophotometric method for the estimation of Exemestane tablets. The determination of exemestane in tablet dosage form has been created using a straightforward, accurate, and economical spectrophotometric approach. The ideal circumstances for the drug's analysis were developed. The maximum wavelength ( \(\lambda\) max) was found to be 246 nm. The percentage recovery of Exemestane was noticed to be 98.7\(\pm\)0.4. Beers law was obeyed in the concentration range of 2-14 \(\mu\)g/mL. The absorbance and concentration have a linear relationship, according to calibration curves. The line equation y=0.05954x+0.0000 with r²  of 0.9938 was obtained. Validation was carried out in accordance with ICH guidelines for linearity, accuracy, precision, LOD, and LOQ. The sample solution was stable for 36 hours. The suggested technique may be appropriate for the study of Exemestane in tablet formulation for quality control purposes.