Microwave Synthesis of Substituted 1- Aryl Pyrroles by Clauson-Kaas Reaction Using Oxone as a Catalyst

Abstract

Oxone has been found to be an efficient and rapid medium for the synthesis of novel substituted pyrroles. The present investigation is involving an efficient methodology to synthesize N-Substituted pyrrole derivatives by Clauson Kaas reaction via conventional and microwave irradiation method using catalyst with various solvents. This method involves remarkable advantages such as simple workup, easy experimental setup, high yield and avoiding hazardous solvent. Structures of newly synthesized compounds have been confirmed by ¹HNMR, ¹³CNMR and mass spectra.