Could FXIII Deficiency Influence Intracerebral Hemorrhage after Neurosurgery?
DOI:
https://doi.org/10.9734/bpi/cpms/v8/3222AKeywords:
Factor XIII, coagulation, fibrinolysis, brain tumor, deficiency, hemorrhage, neurosurgery, bleeding, intensive care unit, intracerebralAbstract
The primary goal was to assess the impact of perioperative FXIII levels on ICH after brain surgery. A prospective, 18-month observational study was carried out at a third-level hospital in Spain. It included all consecutive adults (18 years of age or older) who underwent elective brain tumour surgery and stayed in the Neurointensive Care Unit afterward (N-ICU). Younger than 18 years of age, informed refusal, death in the OR, incomplete blood sample or non-tumoral tissue were exclusion criteria.Three blood samples evaluated FXIII levels (A-presurgical, B-postsurgical and C-24 hours after surgery). There were 109 patients in the study. In 39 of them, ICH was finally confirmed (35,78 percent). Inferential analyses revealed a statistical link between ICU stay length (p0,01) and male gender (p0,03) and ICH. The average of FXIII was lower in ICH patients, particularly in the B sample (A 71,2 percent, B 51,57 percent, C 52,14 percent). Acquired FXIIID (70%) after brain tumour surgery increased ICH, suggesting that it could be used as a risk marker for haemorrhage. ICH was also linked to baseline variation, male gender, and a longer stay in the ICU. Normal coagulation tests did not rule out FXIII disorder. FXIIID detection and replacement therapy could become a therapeutic target in future studies.brain tumor
