A Clinico-histopathological Analysis on Abnormal Uterine Bleeding

Abstract

Accurate analysis of endometrial sampling and localization of intrauterine lesions is the goal to effective management and better outcome of problem. Histological characteristics of endometrial biopsy material as assessed by light microscopy remains the diagnostic standard for the diagnosis of endometrial pathology. Abnormal uterine bleeding (AUB) is a common condition that patients and gynaecologists encounter. It has a negative impact on women's quality of life and psychologically. It is of particular significance in developing countries since it contributes to anemia's causes. Abnormal uterine bleeding (AUB) management is incomplete without tissue diagnosis, particularly in perimenopausal and postmenopausal women. The diagnosis of endometrial pathology is still based on the histological characteristics of endometrial biopsy material as determined by light microscopy. This was a prospective observational study. A total of 359 women, who are more than 45 years of age with abnormal uterine bleeding, who needed endometrial curettage were included in the study. A significant association was found between pattern of histopathology & hypertension with a p value of <0.01. Hypertension was more common in patients with atrophic endometrium, endometrial hyperplasia and endometrial malignancy with 12 out of 20, 68 out of 96 and 14 out of 23 patients respectively. Majority of the patients 68 out of 116 with hypertension had endometrial hyperplasia. We found a maximum incidence of AUB in multiparous women. Clinicohistopathological analysis of AUB revealed endometrial hyperplasia in majority of patients.