Bioabsorbable Materials for the Future Treatment of Congenital Heart Disease

Authors

  • Yuichi Matsuzaki Center for Regenerative Medicine, The Abigail Wexner Research Institute at Nationwide Children’s Hospital, Columbus, OH, USA.
  • Toshiharu Shinoka Center for Regenerative Medicine, The Abigail Wexner Research Institute at Nationwide Children’s Hospital, Columbus, OH, USA and Department of Cardiothoracic Surgery, The Heart Center, Nationwide Children’s Hospital, Columbus, OH, USA.

DOI:

https://doi.org/10.9734/bpi/cpms/v2/15839D

Keywords:

Tissue engineering, large animal model, pulmonary valve, aortic patch, pulmonary vein

Abstract

The present study discuss the real needs of regenerative medicine from the standpoint of pediatric cardiovascular surgery, focusing on the current status of regenerative engineering valves, regenerative engineering patches, and regenerative medicine for pulmonary vein stenosis using bioabsorbable materials. Many disciplines of regenerative medicine have used bioabsorbable materials produced from polymeric compounds to enhance tissue regeneration. These materials are good substitutes for autologous tissue in cardiovascular applications such as valves, patches, sutures, vascular grafts, and defect occlusion devices in the treatment of congenital heart disease due to their growth potential. However, there remains a sizable gap between their theoretical advantages and actual clinical application in congenital heart disease. It is important to utilize large animal models with these resorbable, synthetic materials in order to demonstrate the efficacy and safety of these materials prior to human clinical application.

Published

2022-06-21

How to Cite

Yuichi Matsuzaki, & Toshiharu Shinoka. (2022). Bioabsorbable Materials for the Future Treatment of Congenital Heart Disease. Current Practice in Medical Science Vol. 2, 160–178. https://doi.org/10.9734/bpi/cpms/v2/15839D

Issue

Current Practice in Medical Science Vol. 2

Section

Chapters