Investigation of Gomphogyne bonii Gagnep. Extract Profile for Antidiabetic Effect in the Experimental Type 2 Diabetes Model

Abstract

This chapter was designed to assess the antidiabetic effect of G. bonii extract in the experimental study. Diabetes mellitus has developed into a global health threat to society. Particularly those who have diabetes have always had to deal with its problems and the unanticipated side effects of synthetic medications. As a result, there is currently a tendency among researchers to discover novel natural substances that are both safer and successful in the treatment of diabetes. Gomphogyne bonii Gagnep. extract (G. bonii extract) was a herbal-derived product of the Pharmacy Department, Vietnam University of Traditional Medicine. In order to evaluate the antidiabetic effect of G. bonii extract, a type 2 diabetes model was conducted in mice. The main pathogenesis of type 2 diabetes has been associated with peripheral insulin resistance and deficient insulin production due to the dysregulation of insulin secretion. The result of histopathological examination showed that there was a significant improvement in the structure of the liver after 2-week period at the groups treated with G. bonii extract. In terms of histopathological images of the pancreas, no clear effect was observed in the groups treated with G. bonii extract as compared with the The results revealed that G. bonii extract at both doses ameliorated the effects of ALX on the concentration of glucose, total cholesterol (TC), triglyceride (TG), Low-Density Lipoprotein-Cholesterol (LDL-C) and micro-histological images of livers.  Additionally, the G. bonii extract's antidiabetic impact was stronger at a dose of 12 mL/kg b.w./day than it was at a dose of 4 mL/kg b.w/day. As a result, it was hypothesised that G. bonii extract might one day be used in clinical settings to treat diabetes mellitus.