Bio-applications of Bacterial Cellulose and Type I Collagen Conjugated with Resveratrol for Epithelial Defect Regeneration

Authors

  • Juin-Hong Cherng Department and Graduate Institute of Biology and Anatomy, National Defense Medical Center, 114 Taipei, Taiwan, R.O.C and Department of Gerontological Health Care, National Taipei University of Nursing and Health Sciences, 112 Taipei, Taiwan, R.O.C.
  • Shu-Jen Chang Division of Rheumatology/Immunology/Allergy, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, 114 Taipei, Taiwan, R.O.C.
  • Dewi Sartika Laboratory of Adult Stem Cell and Tissue Regeneration, National Defense Medical Center, 114 Taipei, Taiwan, R.O.C.
  • Cheng-Che Liu Department of Physiology and Biophysics, Graduate Institute of Physiology, National Defense Medical Center, 114 Taipei, Taiwan, R.O.C.
  • Sheng-Tang Wu Division of Urology, Department of Surgery, Tri-Service General Hospital, National Defense Medical Center, 112 Taipei, Taiwan, R.O.C.
  • En Meng Division of Urology, Department of Surgery, Tri-Service General Hospital, National Defense Medical Center, 112 Taipei, Taiwan, R.O.C.

DOI:

https://doi.org/10.9734/bpi/cpcs/v11/7680D

Keywords:

Bacterial cellulose, collagen, resveratrol, biodegradable polymer biomaterials, epidermal reconstruction, tissue regeneration, wound healing

Abstract

Excellent wound dressing is essential for effective wound repair and regeneration. This chapter aims to evaluate the effectiveness of bacterial cellulose (BC) and type I collagen (COL) scaffolds conjugated with resveratrol (RSV) for wound management. BC and COL are biodegradable and renewable attractive polymers for medical applications which has a strong affinity for materials containing hydroxyl groups, meanwhile RSV has a 4'-hydroxyl group and exhibits good biocompatibility and no cytotoxicity. The results demonstrated that RSV was effectively released from the BC and COL scaffolds in vitro, and immunofluorescence staining showed that both scaffolds were highly biocompatible and regenerated epithelia. Additionally, Masson’s trichrome staining showed that the both scaffolds preserved the normal collagen-bundling pattern and induced re-epithelialization in defective rat epidermis. These results indicate that RSV-conjugated BC or COL scaffold created a biocompatible environment for stem cell attachment and growth and promoted epithelial regeneration during wound healing.

Published

2021-06-02

How to Cite

Juin-Hong Cherng, Shu-Jen Chang, Dewi Sartika, Cheng-Che Liu, Sheng-Tang Wu, & En Meng. (2021). Bio-applications of Bacterial Cellulose and Type I Collagen Conjugated with Resveratrol for Epithelial Defect Regeneration. Current Perspectives on Chemical Sciences Vol. 11, 170–190. https://doi.org/10.9734/bpi/cpcs/v11/7680D

Issue

Current Perspectives on Chemical Sciences Vol. 11

Section

Chapters