Host-Guest Inclusion Complex of \(\beta\)-Cyclodextrin of a Biologically Active Compound with the Manifestation of Diverse Interactions: An Advanced Study Approach

Authors

  • Habibur Rahaman Pedong Government College, Kalimpong, 734311, India.
  • Niloy Roy Department of Chemistry, University of North Bengal, Darjeeling, 734013, India.
  • Aditi Roy Department of Chemistry, University of North Bengal, Darjeeling, 734013, India.
  • Samapika Ray Department of Chemistry, University of North Bengal, Darjeeling, 734013, India.
  • Baishali Saha Department of Chemistry, University of North Bengal, Darjeeling, 734013, India.
  • Indubhusan sarkar Department of Chemistry, Alipurduar University, Alipurduar-736122, India.
  • Subhajit Debnath Department of Chemistry, University of North Bengal, Darjeeling, 734013, India.
  • Moumita Kundu Department of Chemistry, University of North Bengal, Darjeeling, 734013, India.
  • Rinku Chakrabarty Department of Chemistry, Alipurduar University, Alipurduar-736122, India.
  • Mahendra Nath Roy Department of Chemistry, University of North Bengal, Darjeeling, 734013, India.

DOI:

https://doi.org/10.9734/bpi/costr/v3/3350B

Keywords:

B-cyclodextrin (B-CD), para nitro-benzaldehyde (PNB), inclusion complex (IC), scanning electron microscope (SEM)

Abstract

The present study aims to explore the formation, carrying and controlled release of PNB by forming IC with CD without any chemical and biological modification of the guest molecule. Cyclodextrins (CYDs) are made up of 6, 7 and 8 glucopyranosyl units attached to \(\alpha\)-(1, 4)-glycosidic linkages are identified as \(\alpha\), \(\beta\), \(\gamma\)-Cyclodextrins respectively. The CYDs are of biomedical and pharmaceutical interest are cyclic oligosaccharides composed of six to eight dextrose units connected through one to four bondsThe host–guest interaction of p-nitro benzaldehyde as guest \(\beta\)-Cyclodextrins have been investigated which have significant applications in the field of medicine such as controlled drug delivery. The 1H NMR study confirms the formation of inclusion complex while surface tension and conductivity studies support the formation inclusion complex with 1:1 stoichiometry. The Job's plot approach and UV-visible spectroscopy were both used to support the stoichiometry of the inclusion complex. The inclusion process is additionally supported by FT-IR spectra and SEM research. The Benesi-Hildebrand method was used to compute the association constants of the inclusion complexes, and the van't Hoff equation was used to estimate the thermodynamic parameters.

Published

2022-09-06

How to Cite

Habibur Rahaman, Niloy Roy, Aditi Roy, Samapika Ray, Baishali Saha, Indubhusan sarkar, … Mahendra Nath Roy. (2022). Host-Guest Inclusion Complex of \(\beta\)-Cyclodextrin of a Biologically Active Compound with the Manifestation of Diverse Interactions: An Advanced Study Approach. Current Overview on Science and Technology Research Vol. 3, 120–135. https://doi.org/10.9734/bpi/costr/v3/3350B

Issue

Current Overview on Science and Technology Research Vol. 3

Section

Chapters