Study on Formulation and In-vitro Characterization of Floating Microspheres of Lamivudine

Abstract

The current study was concerned with the formulation and in vitro evaluation of floating microspheres of lamivudine  by inclusion of different concentrations of HPMC K 100M, to increase the gastric residence time of lamivudine and reduced dosage frequency. Floating drug delivery system is one of the methods to increase the gastric residence time. Preformulation studies performed to confirm the purity of drug and to find the drug excipient interactions with FTIR studies. The ionotropic gelation process was used to create the gastro retentive floating microspheres. For SEM analysis, in-vitro buoyancy studies, and in-vitro dissolving studies, the produced microspheres were assessed. By using FTIR and DSC analysis, the compatibility of the medicine and excipient was verified.  According to in-vitro drug release studies, formulation F5, which contains HPMC K100M as a release retardant polymer at a concentration of 1:2 to the drug, was able to sustain drug release for up to 14 hours. The Korsmeyer equation and Higuchi's model were used to determine that the drug release mechanism from the floating microspheres was anomalous (non-Fickian) diffusion. Using HPMC K100M as a release retardant polymer, the gastro retentive floating microspheres of lamivudine were successfully created and evaluated. Using the formulation F5 with HPMC K100M at 1:2 concentrations to the drug, a slow and spread-out drug release lasting up to 14 hours was observed.