Optimization Extraction Conditions of Some Flavonoids from Elsholtzia ciliata Leaves by Response Surface Method

Authors

  • Truong Nhan Ngu Department of Natural Sciences and Technology, Tay Nguyen University, 567 Le Duan, Buon Ma Thuot, Dak Lak 630000, Vietnam.
  • Dam Thi Bich Hanh Department of Science and Technology, Tay Nguyen University, 567 Le Duan Str., Buon Ma Thuot, Dak Lak province, 630000, Vietnam.
  • Trinh Ngoc Thao Vy Department of Medicine and Pharmacy, Tay Nguyen University, 567 Le Duan Str., Buon Ma Thuot, Dak Lak province, 630000, Vietnam
  • Van-Tinh Nguyen Applied Biomedical Research Institute, Buon Ma Thuot Medical University, 298 Ha Huy Tap Street, Buon Ma Thuot, Dak Lak, 630000, Vietnam.
  • Phi-Hung Nguyen Institute of Natural Products Chemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Caugiay, Hanoi 122100, Vietnam.
  • Manh Hung Tran School of Medicine & Pharmacy, The University of Danang, Hoa Quy, Ngu Hanh Son, Da Nang City 550000, Vietnam.
  • Dao-Cuong To Phenikaa University Nano Institute (PHENA), Phenikaa University, Yen Nghia, Ha Dong District, Hanoi 12116, Vietnam.

DOI:

https://doi.org/10.9734/bpi/cops/v9/4964C

Keywords:

Elsholtzia ciliata, response surface method, ethyl gallate, rutin, apigenin, quercetin

Abstract

In this study, the extraction conditions of several flavonoid compounds from Elsholtzia ciliata leaves were optimized by the response surface method (RSM). The experiment was arranged according to the Box - Behnken design with 15 experiments and was built based on an optimized process for the extraction of ethyl gallate (Y1), rutin (Y2), apigenin (Y3), and quercetin (Y4) with 3 factors of extraction temperature (X1), extraction time (X2) and pressure (X3). The conditions for optimizing the extraction process to obtain the highest content of some flavonoid compounds were at \(57^{\circ}\)C, 54 minutes, and 100 bar pressure. The experimental values at the optimal parameters of ethyl gallate, rutin, apigenin, and quercetin are 97.65 ± 0.32 mg/100g, 35.50 ± 0.25 mg/100g, 17.62 ± 0.15 mg/100g, and 27.66 ± 0.20 mg/100g, respectively.

Published

2023-04-05

How to Cite

Truong Nhan Ngu, Dam Thi Bich Hanh, Trinh Ngoc Thao Vy, Van-Tinh Nguyen, Phi-Hung Nguyen, Manh Hung Tran, & Dao-Cuong To. (2023). Optimization Extraction Conditions of Some Flavonoids from Elsholtzia ciliata Leaves by Response Surface Method. Current Overview on Pharmaceutical Science Vol. 9, 84–98. https://doi.org/10.9734/bpi/cops/v9/4964C

Issue

Current Overview on Pharmaceutical Science Vol. 9

Section

Chapters