Hyperglycemic Control of Moringa oleifera Leaves Aqueous Extract and Glibenclamide Tablets in Alloxan Monohydrate Induced Diabetic Rats: A Comparative Analysis
DOI:
https://doi.org/10.9734/bpi/cops/v9/17898DKeywords:
M. oleifera, alloxan induced diabetes, glibenclamide, hypoglycemia, Wistar ratsAbstract
This chapter aims to compare the hyperglycemic control of M. oleifera leaves aqueous extract and Glibenclamide tablet in alloxan monohydrate induced diabetic rats.
In this experiment, Twenty-four female Wister albino rats, made diabetic using alloxan monohydrate, received either M. oleifera extract, glibenclamide or distilled water were delivered intragastric.
The findings showed that Rats that received distilled water had a mean fasting blood sugar of 329.3+44.9mg/dl at the beginning, which increased to 448.0+189.9mg/dl on day 14, all the rats were dead by day 21. The rats that received M. oleifera had blood sugar 443.4+134.7mg/dl at the beginning, dropped to 166.5+162.79mg/dl by day 14, and to 88.7+41.0 mg/dl by day 28. Rats that received glibenclamide had blood sugar 517.6+139.3mg/dl at the beginning, dropped to 209.0+201.9mg/dl on day14, and to 89.7+42.85mg/dl on day 28. The blood sugar levels in the M.oleifera and glibenclamide groups returned to normal by day 21 and remained within the normal range until the experiment was completed on day 28. Based on the findings of this study, it can be concluded that Moringa oleifera leaves aqueous extract has similar pattern to glibenclamide tablet in causing hypoglycemia to alloxan monohydrate induced diabetic rats.
