Evaluation of Novel-Designed Isatin Derivatives Compounds against a Few Fungal Species

Abstract

Isatin is an organic compound called tribulin, indanedione, and indole quinone which is derived from indole (1H-indole-2,3-dione). Its various derivatives typify an important class of heterocyclic compounds that can be mostly used for drug synthesis as a predecessor. It was reported that its various derivatives have many important biological activities such as anti-cancer, anti-bacterial, anti-diabetic, and others. In this research article, some new spiro derivatives of isatin were synthesized by two different pathways. The chalcones were prepared by the reaction of different acetophenones and isatins via base-catalyzed condensation followed by the addition of acid. The compounds have been characterized by UV-Vis, FT-IR, 1H-NMR,13C-NMR, and Mass spectra. The main objective of the present investigation is to design, synthesize and evaluate isatin derivatives for their possible antimicrobial activities subjected to in vitro antifungal activity against various fungal spores like Aspergillus nigrum and in vitro antioxidant activity. It was found that the compounds exhibited moderate to significant antibacterial, antifungal, and antioxidant activities.