Phytochemical Composition and Antioxidant Activity of Flavonoid-Rich Extracts of Elsholtzia ciliata Collected in Dak Lak Province, Vietnam

Authors

  • Dao-Cuong To Phenikaa University Nano Institute (PHENA), Phenikaa University, Yen Nghia, Ha Dong District, Hanoi 12116, Vietnam and Phenikaa Research and Technology Institute (PRATI), A&A Green Phoenix Group JSC, 167 Hoang Ngan, Cau Giay District, Hanoi 11313, Vietnam.
  • Truong Nhan Ngu Department of Natural Sciences and Technology, Tay Nguyen University, 567 Le Duan, Buon Ma Thuot, Dak Lak 630000, Vietnam.
  • Van-Tinh Nguyen Applied Biomedical Research Institute Buon Ma Thuot University of Medicine, 298 Ha Huy Tap Street, Buon Ma Thuot, Dak Lak, 630000, Vietnam.
  • Dam Thi Bich Hanh Department of Natural Sciences and Technology, Tay Nguyen University, 567 Le Duan, Buon Ma Thuot, Dak Lak 630000, Vietnam.
  • Truong Ba Phong Department of Natural Sciences and Technology, Tay Nguyen University, 567 Le Duan, Buon Ma Thuot, Dak Lak 630000, Vietnam.
  • Phi-Hung Nguyen Institute of Natural Products Chemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Caugiay, Hanoi 122100, Vietnam.
  • Manh Hung Tran School of Medicine & Pharmacy, The University of Danang, Hoa Quy, Ngu Hanh Son, Da Nang City 550000, Vietnam.

DOI:

https://doi.org/10.9734/bpi/cops/v6/4304C

Keywords:

Elsholtzia ciliata, methanol extract, flavonoid, antioxidant, DPPH assay

Abstract

Elsholtzia ciliata (Thunb.) Hyland (Lamiaceae) is widely distributed in the Central Highlands (Tay Nguyen) and Southern Vietnam. In traditional medicine, E. ciliata has been used for the treatment of colds, fever, flu, headache, dizziness, rheumatism, pharyngitis, abdominal pain, diarrhea, vomiting, measles, and itchy sores. This study aimed to determine the total flavonoid content by high-pressure liquid extraction method and evaluate the antioxidant activity of flavonoid-rich extracts of E. ciliata collected in the three regions in Dak Lak province. The methanol extracts were obtained by high-pressure liquid extraction method from the leaves of E. ciliata collected in Buon Ma Thuot city (KG-BMT), Cu M'gar district (KG-CM), and Buon Don district (KG-BD). The total flavonoid content (TFC) from the methanol extracts obtained in three regions was 82.30696 mg quercetin equivalent (QE)/g extract for the Cu M'gar district, 62.26035 mg QE/g extract for the Buon Don district, and 27.08587 mg QE/g extract for Buon Ma Thuot city. The methanol extracts showed high levels of antioxidant capacity in the 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay with IC50 ranging from 0.70 to 1.98 mg/mL. Flavonoid compounds were identified as apigenin, apigenin-O-b-glucoside, ethyl gallate, catechin, epicatechin, and quercitrin from the methanol extracts in three regions by ultra-high performance liquid chromatography (UHPLC).

Published

2023-02-04

How to Cite

Dao-Cuong To, Truong Nhan Ngu, Van-Tinh Nguyen, Dam Thi Bich Hanh, Truong Ba Phong, Phi-Hung Nguyen, & Manh Hung Tran. (2023). Phytochemical Composition and Antioxidant Activity of Flavonoid-Rich Extracts of Elsholtzia ciliata Collected in Dak Lak Province, Vietnam. Current Overview on Pharmaceutical Science Vol. 6, 16–32. https://doi.org/10.9734/bpi/cops/v6/4304C

Issue

Current Overview on Pharmaceutical Science Vol. 6

Section

Chapters