2-Amino-N-(Substituted Alkyl) Benzoxazole-5- Carboxamide Derivatives as Antiinflammatory and Antioxidant Drugs

Authors

  • Arunadevi Parlapalli Department of Pharmaceutical Chemistry, University College of Pharmaceutical Sciences, Kakatiya University, Warangal 506009, India.
  • . Kishore Department of Pharmaceutical Chemistry, University College of Pharmaceutical Sciences, Kakatiya University, Warangal 506009, India.
  • Manasa Cidda Department of Pharmaceutical Chemistry, University College of Pharmaceutical Sciences, Kakatiya University, Warangal 506009, India.
  • Sarangapani Manda Department of Pharmaceutical Chemistry, University College of Pharmaceutical Sciences, Kakatiya University, Warangal 506009, India.

DOI:

https://doi.org/10.9734/bpi/cops/v2/8236F

Keywords:

Benzoxazole, synthesis, antiinflammatory, antioxidant

Abstract

The objective of the Present work is to synthesize, characterization and Pharmacological evaluation of 2-Amino-N-(substituted alkyl) benzoxazole-5- carboxamides for anti-inflammatory and antioxidant activities starting from 4-carbomethoxynitrophenol. Evaluation of the compounds showed Vc(R=ethyl), Ve(R=propyl) and Vg (R=diisopropyl) V g (R=propyl) as the most powerful ones. When compared to the standard ascorbic acid, compound Vf (R=isopropyl) demonstrated a substantially higher percentage of free radical scavenging activity with an IC 50 of 4.65. Vf is regarded as a medication that has both anti-inflammatory and antioxidant properties.

Published

2023-01-12

How to Cite

Arunadevi Parlapalli, . Kishore, Manasa Cidda, & Sarangapani Manda. (2023). 2-Amino-N-(Substituted Alkyl) Benzoxazole-5- Carboxamide Derivatives as Antiinflammatory and Antioxidant Drugs. Current Overview on Pharmaceutical Science Vol. 2, 81–91. https://doi.org/10.9734/bpi/cops/v2/8236F

Issue

Current Overview on Pharmaceutical Science Vol. 2

Section

Chapters