A Review Study on Screening of Non-Steroidal Anti-Inflammatory Drug Using Experimental Animal Models for Inflammatory Diseases

Abstract

The objective of the present study is to review on current available screening methods for evaluation of non-steroidal anti-inflammatory drug(s) using experimental animal models. Inflammation is a natural innate internal defence mechanism that plays a vital role in healing processes. But the excessive response of inflammation may lead to serious health problems in human body. In such cases, various anti-inflammatory drugs such as steroidal and non-steroidal, are being used from time immemorial to treat inflammatory diseased conditions. But the use of these medicines has been associated with serious side effects and toxicities and thus there is a need to investigate novel anti-inflammatory drugs that were having fewer side effects. As per reports various animal models are used for preclinical studies using newer medicines to evaluate and manage possible anti-inflammatory effects. There are several experimental in vivo models that were prescribed for assessing pharmacological anti-inflammatory activities. However, selecting an appropriate animal model for systemic evaluation of anti-inflammatory effects is quite found to be critical enough. This chapter raised current issues in connection to in vivo animal models utilizing for screening of non-steroidal anti-inflammatory drugs. These screening methods also involves pathophysiological studies for inflammatory conditions of each model respectively.