Preliminary Screening Workers Exposed to 4,4’-Methylenebis(2-Chloroaniline) (MBOCA) for Bladder Cancer in Taiwan

Abstract

A program to monitor 4,4’-Methylenebis(2-chloroanilin) (MBOCA) levels in the work environment and to screen for bladder cancer was performed at four MBOCA manufacturing factories in Taiwan. The results of this study have identified a proven bladder carcinoma in MBOCA manufacturing factories. In addition, 1 worker with suspected malignant cells on urine cytology and 1 worker with atypical cytology combined with gross hematuria were identified. The experimental study with mice also showed that MBOCA may be highly toxic and a carcinogen.