Determining the Anti-Inflammatory and Anti-Microbial Activity of Chalcone from Dalbergia sissoo Roxb. Leaves

Abstract

In present work isolation and characterisation of a chalcone [(E)-3-(3,4-dihydroxyphenyl)-1-(2,3,4-trihydroxyphenyl) prop-2-en-1-one] or okanin has been described. The isolation was based on bio-assay guided fractionation. The methanol, hexane extracts and isolated okanin from methanol extracts were exhibited good antibacterial activity towards various pathogens gram positive (Micrococcus luteus and Staphlcocous aureus) and gram negative bacteria (Escherichia coli, R. planticola and Acinetobacter). The anti-inflammatory activity of hexane extracts, methanol extracts of Dalbergia sisso Roxb and okanin have been studied. The methanolic extract showed maximum activity. Dried leaves of Dalbergia sissoo is exhibited antibacterial, antiprotozoal, anti-inflammatory activity. This is the first report of any chalcone from the genus Dalbergia. The finding suggests more research would be required for presence of new phytoconstituents.