Study on Formulation and Evaluation of Famotidine Tablets Prepared by Using Guava Starch as Binding Agents

Abstract

Objective: The release of drug is influencedby various excipients used in formulation. Binders play an important role in drug release in the case of tablets. Thus, the following study attempts to improve a drug's solubility and dissolution rate through the use of natural excipients (Guava Starch).

Methods: The unripe fruit of guava has high content of starch and hence it can be used as a material for extraction of starch. The extracted starch was then evaluated and used as a binder in famotidine tablets at various concentrations. The tablets were created using the wet granulation method and guava starch concentrations of 2% w/v, 4% w/v, 6% w/v, and 8% w/v. The formulated famotidine tablets were then tested for weight variation, hardness, friability, disintegration time, and in-vitro drug release.

Results: The obtained starch is both qualitatively and quantitatively comparable to standard starch. The hardness and disintegration time of the tablets were found to increase as the starch concentration increased. Tablets with highest binder concentration showed maximum hardness (6.0 kg) and disintegration time (8.0 min) and minimum friability (0.76%). After one hour, tablets containing 4% w/v starch had the highest drug release (83.54 percent).

Conclusion: The results of various tests show that guava starch has significant binding properties. As a result, it can be used in pharmaceutical formulations as a tablet binder.