Diclofenac Diethylamine Sprays without Propellant

Abstract

The objective of research work was an attempt to develop non-pressurized topical spray formulation to improve diclofenac diethylamine permeation through lipoidal membrane obstruction. A prototype formulation and thirty formulations were prepared (using different concentration of permeation enhancer, cooling, buffering, film forming agent, plasticizer and lecithin), their characterization & optimization was done (FTIR spectroscopy, drug release, skin-irritation, kinetics study performed by construct the plot of zero order/first order/Higuchi/Korsmeyer Peppa’s). A screw neck HDPE bottle procured with metered spray (200 mcl) pump and actuator was selected as a dispensing system. The spray pump operates on mechanical energy provided by depression of actuator. The result demonstrated drug release of optimized formulation (F30) was found to be 93.3%±3.1 µgcm^-2 and its in-vitro study revealed significant plus immediate topical drug permeation. According ton>value of F30 showed super case (II) transport, erosion release mechanism, moreover no skin-irritation score. Study objective is to reduce cost of the formulation and to make formulation environmental friendly.