Anti-proliferative Effect on Breast Cancer Cell Line via Novel Biogenic Peptide Functionalized Silver Nanoparticles Synthesized from Aloin

Abstract

The current study aims to synthesise silver (Ag) nanoparticles using Aloin with a focus on antibacterial, antioxidant, and anticancer activity. The biosynthesis of nanoparticles has been designed as a profitable and environmentally friendly alternative to chemical and physical methods.

The UV-Visible spectrum was used to determine the silver nanoparticles, which were synthesised using Aloin. Scanning electron microscopy (SEM), zeta potential, and dynamic light scattering (DLS) were used to further characterise it. The Aloin was also subjected to a Fourier transform infrared analysis.The absorption peak at 439nm in the UV-Visible absorption spectrum of the synthesised silver nanoparticles demonstrates the formation of silver nanoparticles in solution. The shape of the Ag nanoparticles was revealed by SEM analysis. The IR spectra revealed that Aloin extract contains six functional groups. The nanoparticles synthesised are highly stable, with an average particle size of 130.7nm, as confirmed by zeta potential and DLS analysis. The nanoparticles produced were antibacterial and antioxidant in nature. It has a strong cytotoxic effect on breast cancer cell lines.  According to the current study, the synthesis route can be used on a large scale in the food industry for food preservation and these Ag nanoparticles can be used for its therapeutic purposes to develop a new drug to treat cancer because it is not dependent on factors like high energy, prolonged preparation times, and specialised equipment.