A Systematic Review on Metabolite Profiling in Anticancer Drug Development

Abstract

One of the most important pharmacokinetic processes is drug metabolism, which is crucial to medication development. The examination of the metabolite profile is essential because the metabolites produced may be helpful for therapy or cause major harm. The objective of this systematic review is to summarize the research articles relating to the metabolite profile investigation of conventional drugs and herb-derived compounds for cancer chemotherapy, to examine factors influencing metabolite profiling of these drugs/compounds and determine the relationship between therapeutic efficacy and toxicity of their metabolites. The literature search was performed through PubMed, and ScienceDirect searches up to January 2019. It was discovered that the creation of metabolites was influenced by four primary variables, including species, gender, drug administration route, and dose. There are certain metabolites that have been classified as hazardous or active.  This information is important for cancer chemotherapy and the development of anticancer drugs.