Therational Design of Precision Drugs

Abstract

Perfect precision medications must be rationally designed by accurately characterising the disease's molecular target. This article discusses how the present medication development process should adapt in order to meet this demand. The article uses examples from previous drug development to show what needs to be done to get to the next step, which is the development of precision drugs-drugs that target diseases with no, or very few, adverse effects. To this goal, distinctive molecular structures linked to diseases must be identified, followed by the development of medications that bind to these structures specifically. Finally, this new paradigm must be adopted in future drug development.