Modern Pharmaceutical Technologies for Drug Targeting: A Review on Colon Specific Drug Delivery Systems

Abstract

The aim of present review is to highlights the significance of modern pharmaceutical approaches for drug targeting to colonic region for successful drug delivery at the desired site of actions. During last few decades globally an ample amount of research and development has been taken place into the field of colon drug targeting due to its potential pharmacological benefits. Colon delivery systems have proven itself as potential drug carriers for the treatment of numerous diseases, reduced side effects, prevents drug from assaults of acidic and alkaline medium of upper GI tract, reduce dose dumping etc. on other hand. The present article highlights for various strategies or technologies that have been explored for colon targeting viz., time dependent system, intestinal pressure-controlled colon delivery capsules, CODES™ technology, pH-dependent systems, enzyme-triggered systems, receptor-mediated systems, etc. for possible potential pharmaceutical therapeutic applications.