A Review on Designing and Formulation Approaches for Development of Novel Colon Specific Drug Delivery Systems

Abstract

The objective of the recent review article is to study on factors governing for designing and formulation approaches for development of the potential colon specific drug delivery systems. Those factors were affecting the overall drug release pattern out from the delivery systems, drug absorption and bioavailability at the site of actions. It is also reviewed on role and affects of those inert polymers that were using in the form of matrix or reservoir into the formulations. Drug delivery systems using for colon targeting has potential for treatment of numerous diseases such as colonic cancer, ulcerative colitis, irritable bowel syndrome, Crohn’s disease, etc. During the last few decades, it has been established that the colonic region has potential for both local and systemic drug absorption efficiently as per reports of various researchers. These methodology based delivery systems were affected with one or more factors viz., gastrointestinal (GI) anatomy and physiology, pH differences, presence of microflora, transit time, fluid volume etc. of human body.  This present article highlights for few approaches that have been explored for dosage form development for colon targeting that contains drug candidate(s) utilizing for all possible therapeutic benefits.