Recent Advancements of In-vitro and In-vivo Evaluation Strategies for Colonic Delivery Systems: An Overview

Abstract

The objective of present current review article covers recent advancements explored for in-vitro and in-vivo evaluation strategies of colonic delivery systems and its potential pharmaceutical applications. Colon targeted drug delivery systems are designed in such a manner that by passes premature drug release into upper hostile bio-environment of gastro intestinal (GI) tract, while directly release of content on arrival into colonic region only. Hence this article highlight on those in-vitro and in-vivo evaluation strategies that utilize to confirms for resistance of delivery systems from assaults of upper bio-environment of GI tract viz., GI motility, pH changes from acidic to alkaline medium, fluid contents, gastro enzymatic activity etc. effectively. Those reported evaluation parameters help us to overcome the limitations of formulation and confirms for successful development of drug delivery devices for colon specific targeting. This review also focussed on utilization of few polysaccharides as an excipient materials for development of various colon-targeted formulations.