Nanoparticles as a Delivery System for Conventional drugs and Herb-Derived Compounds for Cancer Therapy

Authors

  • Abdifetah Ibrahim Omar Chulabhorn International College of Medicine, Thammasat University, Pathumthani, Thailand and Center of Excellence in Pharmacology and Molecular Biology of Malaria and Cholangiocarcinoma, Chulabhorn International College of Medicine, Thammasat University, Pathumthani, Thailand.
  • Nadda Muhamad Chulabhorn International College of Medicine, Thammasat University, Pathumthani, Thailand and Center of Excellence in Pharmacology and Molecular Biology of Malaria and Cholangiocarcinoma, Chulabhorn International College of Medicine, Thammasat University, Pathumthani, Thailand.
  • Tullayakorn Plengsuriyakarn Chulabhorn International College of Medicine, Thammasat University, Pathumthani, Thailand and Center of Excellence in Pharmacology and Molecular Biology of Malaria and Cholangiocarcinoma, Chulabhorn International College of Medicine, Thammasat University, Pathumthani, Thailand.
  • Kesara Na-Bangchang Chulabhorn International College of Medicine, Thammasat University, Pathumthani, Thailand and Center of Excellence in Pharmacology and Molecular Biology of Malaria and Cholangiocarcinoma, Chulabhorn International College of Medicine, Thammasat University, Pathumthani, Thailand and Drug Discovery Center, Thammasat University, Pathumthani, Thailand.

DOI:

https://doi.org/10.9734/bpi/capr/v3/15967D

Keywords:

Anticancer, chemotherapy, herb-derived compounds, nanoparticles pharmacokinetics, traditional medicines

Abstract

The objective of the article is to examine the application of pharmacokinetic studies of nanoparticles loaded in conventional drugs and herb-derived compounds for cancer therapy. Several herbal remedies and chemotherapy medications incorporated into nanoparticles had their pharmacokinetic properties described. This included area under the curve (AUC) of plasma concentration-time profile, maximum plasma concentration (Cmax), time to maximum plasma concentration (Tmax), volume of distribution (Vd or Vss), elimination half-life (t ½), and clearance (CL). The systematic review was carried outusing the databases of PubMed and Science Direct until February 2019. Polymeric nanoparticles were the most widely utilized nanocarrier to improve pharmacokinetic characteristics, according to this systematic review. Nanoparticles as a novel drug delivery technology have the potential to improve the pharmacokinetics and cytotoxicity of loaded drugs/herb-derived compounds for cancer therapy.

Published

2022-05-19

How to Cite

Abdifetah Ibrahim Omar, Nadda Muhamad, Tullayakorn Plengsuriyakarn, & Kesara Na-Bangchang. (2022). Nanoparticles as a Delivery System for Conventional drugs and Herb-Derived Compounds for Cancer Therapy. Challenges and Advances in Pharmaceutical Research Vol. 3, 77–103. https://doi.org/10.9734/bpi/capr/v3/15967D

Issue

Challenges and Advances in Pharmaceutical Research Vol. 3

Section

Chapters