Advanced Formulation Techniques to Enhance Solubility, Dissolution and Bioavailability of Poorly Water- Soluble Drugs

Abstract

Bioavailability is the rate and extent (amount) of absorption of an unchanged drug from its dosage form. This is considered as a primary parameter for a drug to show maximum pharmacological response. The poor aqueous-soluble drug can exhibit poor dissolution rates and incomplete absorption resulting in poor bioavailability. The dissolution and solubility parameters of the drug are very important in developing formulation. So, different methods are employed to improve the drugs solubility such as pH adjustment, micronization, solid dispersion, Supercritical fluid recrystallization, complexation, use of surfactants, co-solvency, Precipitation and nanotechnology etc. The main objective of this study is to give an overview of methods to enhance solubility, dissolution, and bioavailability of low aqueous soluble drugs and the importance of Green chemistry in nanotechnology to produce various nanosized formulations.